New research could forge future cure for hearing loss

New research funded by Action on Hearing Loss has brought scientists closer to being able to trigger the regeneration of damaged cells in the inner ear and gives hope to the 10 million people in the UK affected by a hearing loss that a cure can be found.
 
Most hearing loss is caused by the loss of sensory hair cells in the inner ear that detect sound vibrations. The human ear cannot replace these cells, so hearing loss is permanent - but remarkably, zebrafish can regenerate these cells and were used in the study to discover drugs that may lead to the restoration of hearing.

Researchers tested 1680 different drugs and discovered two that enhance the regeneration of sensory hair cells in zebrafish and six drugs that block or slow regeneration.
Professor Rubel who led the study at University of Washington said: ‘This study demonstrates that it is possible to screen large libraries of compounds to find drugs and drug targets that influence hair cell regeneration. It provides some useful targets for future studies. Moreover, it demonstrated the usefulness of and extension of this approach to screen a much wider range of compounds.’

‘Discovering compounds or drugs able to influence regeneration is important as it will help us understand the biological processes involved, providing clues as to how we might be able to trigger regeneration in the human ear. The drugs discovered so far have been shown to interfere with cell division suggesting that the ability of cells to divide in a damaged ear will be key to triggering regeneration.’

Dr Ralph Holme, Head of Biomedical Research at Action on Hearing Loss said: ‘We are very excited by this research as it opens the door to the possibility that drugs able to trigger the regeneration of hair cells in the inner ear will be found in the future, revolutionising the way hearing loss is currently treated.’

Have You Heard...Hearing Loss

Hearing loss, or deafness, is the partial or total inability to hear sound in one or both ears.

The human ear is amazing. It is one of the smallest and most complex organs in the body, capable of turning the tiniest disturbances in air molecules into a form the brain can understand - and doing so instantaneously, over an enormous range of pitch and loudness. Considering the ear's delicacy, it is remarkably resilient. Nevertheless, illness or injury can impair our ability to hear properly.
In recent years, substantial advances have made it possible to determine the cause of hearing impairment in nearly all cases, and to treat the hearing loss in many ears.

How Does Hearing Loss Affect One's Life?

Virtually no condition in medicine can have as profound an effect on quality of life as even moderate hearing loss in some people.
Hearing loss makes even routine communication difficult. High frequency hearing loss often involves loss of ability to hear consonants such as s, f, t, and z, even though vowels can be heard normally. Consequently, people hear but cannot make out what is being said.
This may result in frustration, withdrawal from social activities, depression, and marital discord. People lose the ability to take in the sounds like bird songs, rustling of leaves, and the voices of children. In general, these infringements on the quality of life can be overcome through medical or surgical treatment or with hearing aids.
When hearing loss occurs early in childhood, its devastating consequences are more obvious than when it occurs late in life. A hearing deficit in infants can interfere with psychological, emotional, and speech development. It also makes learning a mammoth task and can cause frustration or isolation.
Even more mild forms of hearing loss early in life can cause great difficulties, including poor attention and bad grades in school. Frequently, such children are considered "not too bright," before anyone realizes that a hearing loss is present. When it is corrected, the changes in the child's performance, attitude, and interactions are often remarkable.

Key facts

• In 2004, over 275 million people globally had moderate-to-profound hearing impairment, 80% of them in low- and middle-income countries.
• Infectious diseases such as meningitis, measles, mumps and chronic ear infections can lead to hearing impairment. Other common causes include exposure to excessive noise, head and ear injury, ageing and the use of ototoxic drugs.
• Half of all cases of deafness and hearing impairment are avoidable through primary prevention.
• A large percentage can be treated through early diagnosis and suitable management.
• Depending on the cause of hearing loss, it may be treated medically, surgically or through devices such as hearing aids and Cochlear Implants.
• Production of hearing aids meets less than 10% of global need. In developing countries, fewer than 1 out of 40 people who need a hearing aid have one.

Newspaper information piece; "Have You Heard"

Each and every single week from Friday 27th onwards Bexhill Hearing Centre will be dispensing a little bit of knowledge in the Bexhill, Hastings, Rye and Battle Observers as well as the local Resident. Tiny snippets of information about the world of hearing, to remind our customers that our knowledge and advice is always available.

From the latest audio technology to hearing loss management, there will be something for everyone, whether you suffer from a hearing loss or not.

Items to be covered in the first 6 weeks include: (in no particular order)

Hearing loss; why it happens
Ear Wax maintenance
History of Hearing Aids
Coping with Tinnitus
Waterproof Hearing
Ototoxicity

We are hoping that the articles will become Blog like, allowing the public to follow the story. They will also be teamed up with further information here and on our website (www.BexhillHearingCentre.com) so that more complete information can be provided.

Famous quotes from history about Hearing

George Bernard Shaw

That is what all poets do: they talk to themselves out loud; and the world overhears them. But it’s horribly lonely not to hear someone else talk sometimes. "(Marchbanks, in Candida)

Bible

Does not the ear test words, as the palate tastes its food? - Job 12:11

Pete Townshend

I have unwittingly helped to invent and refine a type of music that makes its principal components deaf. Hearing loss is a terrible thing because it cannot be repaired.

Samuel Johnson

"In order that all men may be taught to speak the truth, it is necessary that all likewise should learn to hear it."

Bible

He who has ears to hear, let him hear. - Mark, 4:9

Mark Antony

"Friends, Romans, Countrymen, lend me your ears."

Beethoven

"Oh you men who think or say that I am malevolent, stubborn, or misanthropic, how greatly do you wrong me. You do not know the secret cause which makes me seem that way to you. Oh how harshly was I flung back by the doubly sad experience of my bad hearing."

"But what a humiliation for me when someone standing next to me heard a flute in the distance and I heard nothing, or someone standing next to me heard a shepherd singing and again I heard nothing. Such incidents drove me almost to despair; a little more of that and I would have ended my life - it was only my art that held me back. "

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