Have you heard...Ototoxicity

There are more than 200 known ototoxic medications that can damage the ear, resulting in hearing loss, ringing in the ear, or balance disorders. These include medicines used to treat serious infections, cancer, and heart disease.

What are the effects from ototoxic medications?

Usually the first sign of ototoxicity is ringing in the ears (tinnitus). Over time, you may also develop hearing loss. This hearing loss may go unnoticed until your ability to understand speech is affected.
Balance problems can also occur as a result of ototoxic medications. You may experience a loss of balance and feeling unsteady on your feet.. Sometimes these problems are temporary because the human body can learn to adapt to reduced balance control.


What is happening inside the ear to cause these effects?

Ototoxic medications cause damage to the sensory cells used in hearing and balance. These sensory cells are located in the inner ear.

Which medications are ototoxic?

There are more than 200 medications and chemicals that are known to cause hearing and balance problems. It is important to discuss with your doctor the potential for hearing or balance damage of any drug you are taking. Sometimes there is little choice. Treatment with a particular medication may provide the best hope for curing a life-threatening disease or stopping a life-threatening infection.

Ototoxic medications known to cause permanent damage include certain aminoglycoside antibiotics, such as gentamicin (family history may increase susceptibility), and cancer chemotherapy drugs, such as cisplatin and carboplatin.

Drugs known to cause temporary damage include salicylate pain relievers (aspirin, used for pain relief and to treat heart conditions), quinine (to treat malaria), and loop diuretics (to treat certain heart and kidney conditions).

In some instances, exposure to loud noise while taking certain drugs will increase their damaging effects.

What to do before begining treatment with ototoxic medications?

You should monitor your hearing and balance systems before and during treatment. Before starting the treatment, a baseline record of your hearing and balance should be recorded by an audiologist.

This information can help you and your doctor make any important decisions to stop or change the drug therapy before your hearing is damaged.

For cases in which the drugs cannot be stopped or changed, the patient and the audiologist can take steps to manage the effects of the hearing loss that results.

During the course of your treatment, you should have periodic hearing tests as part of the monitoring process. This will help enable you to report any hearing changes, ringing in the ears, or balance problems that you may notice.